Exact doses not always achievable in a natural product

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Exact doses not always achievable in a natural product

Dear Dr. Roach • Recently in your column, you discussed the need for dosages to be exact in some situations. What about the medical marijuana issue? In our small town, there are four dispensaries. If someone truly felt he or she needed it for medical issues, would that person get the same dosage at each location? If the doctor prescribes aspirin, he doesn’t have me go to the willow tree, or to the willow dispensary down the street. — J.O.

Answer • You are exactly right that the content of the active components of marijuana varies from strain to strain and even from plant to plant. This makes getting exact dosages impossible. This is a general problem with natural products, which is why Western medicine has preferred to identify, extract and purify the active ingredients.

There is a potential downside to this philosophy, which is that the purification may remove other substances, which may themselves have an effect or may modify the effect of a substance found in the original natural product. This appears to be the case with marijuana, as there are at least two compounds with important potential medical benefits, tetrahydrocannabinol (THC, which has several subtypes, especially delta-9 and delta-4) and cannabidiol (CBD). The effect of dronabinol (Marinol), a synthetic form of delta-9 THC, is reported as being very different from natural marijuana by most people who have used both, though this may be an effect of dose, of speed of onset, or of expectations. Hence the interest in medical marijuana, with its multiple compounds and ability for growers to emphasize the THC or CBD content.

Recreational users of marijuana have experience in achieving the correct dosage; however, for medical use (such as seizures), that ability isn’t relevant. I suspect the future will include a greater degree of chemical analysis of the THC and CBD content in a given batch.

Readers • The booklet on edema and lymphedema provides information on the causes of foot and ankle swelling. Readers can order a copy by writing:

Dr. Roach

Book No. 106

628 Virginia Dr.

Orlando, FL 32803

Enclose a check or money order (no cash) for $4.75 U.S./$6 Can. with the recipient’s printed name and address. Please allow four weeks for delivery.

Dr. Roach regrets that he is unable to answer individual letters, but will incorporate them in the column whenever possible. Readers may email questions to ToYourGoodHealth@med.cornell.edu or request an order form of available health newsletters at 628 Virginia Drive, Orlando, Fla. 32803. Health newsletters may be ordered from rbmamall.com.

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